2021 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Syracuse | 8 | 72 | 54 | 15 | 141 | 17.6 |
| 2 | Miami (Florida) | 8 | 67 | 64 | 17 | 148 | 18.5 |
| 3 | Boston College | 9 | 79 | 67 | 18 | 164 | 18.2 |
| 4 | Clemson | 9 | 45 | 73 | 10 | 128 | 14.2 |
| 5 | Virginia | 8 | 75 | 76 | 19 | 170 | 21.3 |
| 6 | Florida State | 8 | 68 | 77 | 18 | 163 | 20.4 |
| 7 | North Carolina | 9 | 92 | 80 | 19 | 191 | 21.2 |
| 8 | Louisville | 8 | 65 | 81 | 16 | 162 | 20.3 |
| 9 | North Carolina State | 10 | 63 | 87 | 23 | 173 | 17.3 |
| 9 | Georgia Tech | 8 | 77 | 87 | 14 | 178 | 22.3 |
| 11 | Wake Forest | 11 | 116 | 101 | 24 | 241 | 21.9 |
| 12 | Virginia Tech | 11 | 103 | 102 | 17 | 222 | 20.2 |
| 13 | Pittsburgh | 11 | 59 | 122 | 29 | 210 | 19.1 |
| 13 | Duke | 10 | 92 | 122 | 20 | 234 | 23.4 |