2021 Atlantic Coast Conference Leaders Sacks - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Pittsburgh | 9 | 35.0 | 250 | 3.89 |
| 2 | Clemson | 8 | 32.0 | 208 | 4.00 |
| 3 | Wake Forest | 10 | 29.0 | 184 | 2.90 |
| 4 | North Carolina State | 8 | 28.0 | 150 | 3.50 |
| 5 | Miami (Florida) | 8 | 25.0 | 189 | 3.13 |
| 5 | North Carolina | 9 | 25.0 | 169 | 2.78 |
| 5 | Louisville | 8 | 25.0 | 168 | 3.13 |
| 8 | Syracuse | 8 | 19.0 | 138 | 2.38 |
| 8 | Florida State | 8 | 19.0 | 100 | 2.38 |
| 10 | Virginia Tech | 8 | 16.0 | 110 | 2.00 |
| 11 | Boston College | 8 | 15.0 | 123 | 1.88 |
| 11 | Duke | 8 | 15.0 | 78 | 1.88 |
| 13 | Georgia Tech | 8 | 14.0 | 89 | 1.75 |
| 13 | Virginia | 8 | 14.0 | 84 | 1.75 |