2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | North Carolina | 7 | 7 | 32 | 39 | 5.57 |
| 2 | Clemson | 6 | 5 | 28 | 33 | 5.50 |
| 3 | Virginia | 5 | 3 | 24 | 27 | 5.40 |
| 4 | Pittsburgh | 6 | 9 | 22 | 31 | 5.17 |
| 5 | Duke | 3 | 0 | 14 | 14 | 4.67 |
| 6 | Florida State | 5 | 6 | 16 | 22 | 4.40 |
| 7 | Virginia Tech | 5 | 3 | 17 | 20 | 4.00 |
| 7 | North Carolina State | 4 | 4 | 12 | 16 | 4.00 |
| 7 | Boston College | 3 | 1 | 11 | 12 | 4.00 |
| 10 | Miami (Florida) | 5 | 3 | 13 | 16 | 3.20 |
| 10 | Syracuse | 5 | 2 | 14 | 16 | 3.20 |
| 12 | Louisville | 7 | 2 | 20 | 22 | 3.14 |
| 13 | Wake Forest | 4 | 4 | 8 | 12 | 3.00 |
| 14 | Georgia Tech | 6 | 0 | 8 | 8 | 1.33 |