2021 Atlantic Coast Conference Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 8 | 10 | 35 | 45 | 5.63 |
| 2 | North Carolina State | 10 | 11 | 39 | 50 | 5.00 |
| 2 | Clemson | 9 | 10 | 35 | 45 | 5.00 |
| 4 | Louisville | 8 | 9 | 27 | 36 | 4.50 |
| 5 | Duke | 10 | 8 | 36 | 44 | 4.40 |
| 6 | Virginia | 8 | 5 | 28 | 33 | 4.13 |
| 7 | Wake Forest | 11 | 12 | 32 | 44 | 4.00 |
| 8 | Virginia Tech | 11 | 8 | 35 | 43 | 3.91 |
| 9 | Pittsburgh | 11 | 9 | 32 | 41 | 3.73 |
| 10 | Boston College | 9 | 9 | 24 | 33 | 3.67 |
| 11 | Miami (Florida) | 8 | 6 | 20 | 26 | 3.25 |
| 12 | North Carolina | 9 | 8 | 20 | 28 | 3.11 |
| 13 | Georgia Tech | 8 | 3 | 21 | 24 | 3.00 |
| 14 | Syracuse | 8 | 2 | 19 | 21 | 2.63 |