2021 Atlantic Coast Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 3 | 7 | 157 | 2 | 2.33 |
| 2 | North Carolina State | 2 | 4 | 5 | 0 | 2.00 |
| 3 | Florida State | 4 | 4 | 50 | 0 | 1.00 |
| 3 | Wake Forest | 3 | 3 | 0 | 0 | 1.00 |
| 3 | Virginia Tech | 2 | 2 | 40 | 1 | 1.00 |
| 6 | Virginia | 4 | 3 | 33 | 0 | 0.75 |
| 6 | North Carolina | 4 | 3 | 21 | 0 | 0.75 |
| 8 | Miami (Florida) | 4 | 2 | 39 | 0 | 0.50 |
| 8 | Syracuse | 4 | 2 | 9 | 0 | 0.50 |
| 8 | Clemson | 4 | 2 | 3 | 0 | 0.50 |
| 11 | Boston College | 3 | 1 | 0 | 0 | 0.33 |
| 12 | Louisville | 5 | 1 | 29 | 0 | 0.20 |