2021 Atlantic Coast Conference Leaders Tackles For Loss - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Florida State | 4 | 34.0 | 115 | 8.50 |
| 2 | Miami (Florida) | 4 | 28.0 | 139 | 7.00 |
| 2 | Pittsburgh | 3 | 21.0 | 94 | 7.00 |
| 4 | Clemson | 4 | 23.0 | 100 | 5.75 |
| 5 | Wake Forest | 3 | 17.0 | 81 | 5.67 |
| 6 | Louisville | 5 | 26.0 | 83 | 5.20 |
| 7 | Syracuse | 4 | 20.0 | 94 | 5.00 |
| 7 | North Carolina State | 2 | 10.0 | 30 | 5.00 |
| 7 | Duke | 2 | 10.0 | 21 | 5.00 |
| 10 | North Carolina | 4 | 17.0 | 89 | 4.25 |
| 11 | Boston College | 3 | 11.0 | 34 | 3.67 |
| 12 | Virginia Tech | 2 | 7.0 | 25 | 3.50 |
| 13 | Georgia Tech | 4 | 13.0 | 61 | 3.25 |
| 13 | Virginia | 4 | 13.0 | 45 | 3.25 |