2021 Atlantic Coast Conference Leaders Tackles For Loss - Games in August/September Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Syracuse | 4 | 39.0 | 143 | 9.75 |
| 2 | Wake Forest | 4 | 33.0 | 129 | 8.25 |
| 3 | Pittsburgh | 4 | 30.0 | 161 | 7.50 |
| 3 | Florida State | 4 | 30.0 | 95 | 7.50 |
| 5 | Miami (Florida) | 5 | 37.0 | 157 | 7.40 |
| 6 | Georgia Tech | 4 | 28.0 | 141 | 7.00 |
| 6 | Clemson | 4 | 28.0 | 109 | 7.00 |
| 8 | Virginia Tech | 4 | 27.0 | 113 | 6.75 |
| 9 | Louisville | 4 | 26.0 | 115 | 6.50 |
| 10 | North Carolina | 4 | 23.0 | 86 | 5.75 |
| 11 | Duke | 4 | 22.0 | 81 | 5.50 |
| 12 | Virginia | 5 | 25.0 | 81 | 5.00 |
| 13 | North Carolina State | 4 | 19.0 | 53 | 4.75 |
| 14 | Boston College | 4 | 18.0 | 68 | 4.50 |