2021 Atlantic Coast Conference Leaders First Downs - Games in August/September Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 5 | 49 | 56 | 16 | 121 | 24.2 |
| 1 | Boston College | 4 | 49 | 32 | 5 | 86 | 21.5 |
| 3 | Duke | 4 | 46 | 50 | 4 | 100 | 25.0 |
| 4 | North Carolina | 4 | 44 | 45 | 10 | 99 | 24.8 |
| 4 | Syracuse | 4 | 44 | 30 | 7 | 81 | 20.3 |
| 6 | Pittsburgh | 4 | 43 | 67 | 9 | 119 | 29.8 |
| 7 | Georgia Tech | 4 | 42 | 36 | 6 | 84 | 21.0 |
| 8 | Virginia Tech | 4 | 38 | 36 | 7 | 81 | 20.3 |
| 9 | Wake Forest | 4 | 35 | 46 | 13 | 94 | 23.5 |
| 9 | Florida State | 4 | 35 | 35 | 9 | 79 | 19.8 |
| 11 | Virginia | 5 | 34 | 89 | 11 | 134 | 26.8 |
| 12 | North Carolina State | 4 | 29 | 57 | 13 | 99 | 24.8 |
| 12 | Louisville | 4 | 29 | 51 | 5 | 85 | 21.3 |
| 12 | Clemson | 4 | 29 | 30 | 11 | 70 | 17.5 |