2021 American Athletic Conference Leaders Interceptions - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Coby Bryant | Cincinnati | SR | CB | 9 | 3 | 95 | 1 | 0.33 |
| 2 | Macon Clark | Tulane | JR | S | 8 | 3 | 78 | 0 | 0.38 |
| 3 | Gervarrius Owens | Houston | JR | S | 9 | 2 | 73 | 1 | 0.22 |
| 4 | Antonio Grier | S Florida | SR | LB | 8 | 2 | 69 | 1 | 0.25 |
| 5 | Christian Williams | S Florida | SO | S | 7 | 2 | 61 | 0 | 0.29 |
| 6 | Travon Fuller | Tulsa | SR | CB | 8 | 2 | 60 | 0 | 0.25 |
| 7 | Gleson Sprewell | Houston | SR | S | 8 | 2 | 44 | 0 | 0.25 |
| 8 | Dyllon Lester | UCF | JR | DB | 7 | 1 | 34 | 0 | 0.14 |
| 9 | Shawn Dourseau | ECU | SO | SAF | 8 | 1 | 33 | 0 | 0.13 |
| 10 | Warren Saba | ECU | SR | SAF | 8 | 3 | 31 | 0 | 0.38 |
| 10 | Malik Fleming | ECU | SO | CB | 8 | 1 | 31 | 1 | 0.13 |
| 12 | Rodney Owens | Memphis | SR | DB | 8 | 2 | 25 | 0 | 0.25 |
| 12 | Divaad Wilson | UCF | JR | DB | 8 | 1 | 25 | 0 | 0.13 |
| 12 | Freddie Johnson | Temple | SR | CB | 8 | 1 | 25 | 0 | 0.13 |
| 15 | Tatum Bethune | UCF | JR | LB | 7 | 1 | 23 | 0 | 0.14 |
| 16 | Jalen Ware | Temple | JR | SAF | 6 | 2 | 20 | 0 | 0.33 |
| 17 | Davonte Brown | UCF | SO | DB | 8 | 1 | 14 | 0 | 0.13 |
| 17 | Quindell Johnson | Memphis | JR | DB | 8 | 1 | 14 | 0 | 0.13 |
| 19 | Deshawn Pace | Cincinnati | SO | LB | 9 | 2 | 12 | 0 | 0.22 |
| 20 | Trevor Denbow | SMU | SR | S | 8 | 1 | 11 | 0 | 0.13 |
| 21 | Joel Dublanko | Cincinnati | SR | LB | 9 | 1 | 9 | 0 | 0.11 |
| 22 | Jeremiah Jean-Baptiste | UCF | JR | LB | 7 | 1 | 8 | 0 | 0.14 |
| 22 | Delano Robinson | SMU | SR | LB | 8 | 1 | 8 | 0 | 0.13 |
| 24 | Ja'von Hicks | Cincinnati | SR | S | 9 | 1 | 7 | 0 | 0.11 |
| 25 | Teagan Wilk | ECU | FR | SAF | 7 | 1 | 6 | 0 | 0.14 |
| 26 | Dwayne Boyles | S Florida | SR | LB | 8 | 2 | 4 | 0 | 0.25 |
| 26 | Juan Powell | ECU | FR | SAF | 5 | 1 | 4 | 0 | 0.20 |
| 26 | Kevin Henry | Tulane | SR | LB | 8 | 1 | 4 | 0 | 0.13 |
| 29 | Ahmad Gardner | Cincinnati | JR | CB | 9 | 1 | 3 | 0 | 0.11 |
| 30 | Marcus Jones | Houston | SR | CB | 9 | 5 | 2 | 0 | 0.56 |
| 31 | Jacobi Francis | Memphis | SR | DB | 8 | 2 | 1 | 0 | 0.25 |
| 31 | Jamal Glenn | Navy | SR | CB | 7 | 1 | 1 | 0 | 0.14 |
| 31 | Arquon Bush | Cincinnati | JR | CB | 8 | 1 | 1 | 0 | 0.13 |