2021 American Athletic Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Alex Hogan | Houston | JR | CB | 4 | 1 | 91 | 1 | 0.25 |
| 2 | Justin Wright | Tulsa | JR | LB | 3 | 1 | 55 | 1 | 0.33 |
| 3 | Mekhi LaPointe | S Florida | SR | DB | 3 | 1 | 50 | 0 | 0.33 |
| 4 | Kevin Henry | Tulane | SR | LB | 4 | 1 | 49 | 1 | 0.25 |
| 5 | Bryan Massey | SMU | SO | S | 4 | 1 | 48 | 0 | 0.25 |
| 6 | Ja'Quan McMillian | ECU | SO | CB | 4 | 3 | 43 | 1 | 0.75 |
| 7 | Deshawn Pace | Cincinnati | SO | LB | 3 | 1 | 39 | 0 | 0.33 |
| 8 | Brock Nichols | S Florida | SR | S | 4 | 1 | 38 | 0 | 0.25 |
| 9 | Isaac Slade-Matautia | SMU | JR | LB | 4 | 1 | 35 | 0 | 0.25 |
| 10 | Matthew Hill | S Florida | SO | S | 4 | 1 | 27 | 0 | 0.25 |
| 11 | Isaiah Nwokobia | SMU | FR | S | 4 | 2 | 19 | 0 | 0.50 |
| 12 | Kevin Brennan | Navy | SR | FS | 3 | 1 | 15 | 0 | 0.33 |
| 13 | Lance Robinson | Tulane | SO | DB | 4 | 1 | 13 | 0 | 0.25 |
| 14 | Derrion Rakestraw | Tulane | SR | S | 4 | 1 | 12 | 0 | 0.25 |
| 15 | Manny Walker | Temple | SR | DE | 4 | 2 | 11 | 1 | 0.50 |
| 15 | Ja'von Hicks | Cincinnati | SR | S | 3 | 1 | 11 | 0 | 0.33 |
| 17 | Mbiti Williams Jr. | Navy | FR | CB | 2 | 1 | 7 | 0 | 0.50 |
| 17 | Trevor Denbow | SMU | SR | S | 4 | 1 | 7 | 0 | 0.25 |
| 19 | Arquon Bush | Cincinnati | JR | CB | 3 | 2 | 6 | 0 | 0.67 |
| 20 | Sylvonta Oliver | Memphis | SR | DB | 4 | 1 | 1 | 0 | 0.25 |