2021 American Athletic Conference Leaders Total Offense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Tyjae Spears | Tulane | FR | RB | 2 | 375 | 0 | 43 | 375 | 8.72 | 187.5 |
| 2 | Seth Henigan | Memphis | FR | QB | 4 | 15 | 1273 | 155 | 1288 | 8.31 | 322.0 |
| 3 | Tanner Mordecai | SMU | JR | QB | 7 | 167 | 2265 | 308 | 2432 | 7.90 | 347.4 |
| 4 | Clayton Tune | Houston | JR | QB | 8 | 142 | 2238 | 306 | 2380 | 7.78 | 297.5 |
| 5 | Holton Ahlers | ECU | JR | QB | 5 | 217 | 1427 | 216 | 1644 | 7.61 | 328.8 |
| 6 | Davis Brin | Tulsa | JR | QB | 7 | 79 | 1728 | 238 | 1807 | 7.59 | 258.1 |
| 7 | Keaton Mitchell | ECU | FR | RB | 5 | 622 | 0 | 84 | 622 | 7.40 | 124.4 |
| 8 | Kelley Joiner | S Florida | JR | RB | 3 | 231 | 0 | 32 | 231 | 7.22 | 77.0 |
| 9 | Brandon Thomas | Memphis | FR | RB | 3 | 262 | 0 | 37 | 262 | 7.08 | 87.3 |
| 10 | Michael Pratt | Tulane | FR | QB | 2 | 52 | 458 | 74 | 510 | 6.89 | 255.0 |
| 11 | Desmond Ridder | Cincinnati | SR | QB | 5 | 169 | 1176 | 206 | 1345 | 6.53 | 269.0 |
| 12 | Mikey Keene | UCF | FR | QB | 7 | -8 | 1166 | 187 | 1158 | 6.19 | 165.4 |
| 13 | Justin Lynch | Temple | FR | QB | 5 | 108 | 441 | 96 | 549 | 5.72 | 109.8 |
| 14 | Jerome Ford | Cincinnati | JR | RB | 4 | 370 | 0 | 68 | 370 | 5.44 | 92.5 |
| 15 | Alton McCaskill | Houston | FR | RB | 8 | 651 | 0 | 124 | 651 | 5.25 | 81.4 |
| 16 | Deneric Prince | Tulsa | JR | RB | 6 | 290 | 0 | 56 | 290 | 5.18 | 48.3 |
| 17 | Shamari Brooks | Tulsa | SR | RB | 7 | 691 | 0 | 137 | 691 | 5.04 | 98.7 |
| 18 | Cade Fortin | S Florida | SO | QB | 3 | 14 | 142 | 32 | 156 | 4.88 | 52.0 |
| 19 | Jaren Mangham | S Florida | JR | RB | 3 | 199 | 0 | 41 | 199 | 4.85 | 66.3 |
| 20 | Rodrigues Clark | Memphis | JR | RB | 3 | 182 | 0 | 38 | 182 | 4.79 | 60.7 |
| 21 | Tre Siggers | SMU | SR | RB | 7 | 480 | 0 | 102 | 480 | 4.71 | 68.6 |
| 22 | Edward Saydee | Temple | FR | RB | 5 | 195 | 0 | 45 | 195 | 4.33 | 39.0 |
| 23 | Timmy McClain | S Florida | FR | QB | 3 | 25 | 286 | 75 | 311 | 4.15 | 103.7 |
| 24 | Isaac Ruoss | Navy | SR | FB | 2 | 141 | 0 | 36 | 141 | 3.92 | 70.5 |
| 25 | Rahjai Harris | ECU | FR | RB | 5 | 298 | 0 | 84 | 298 | 3.55 | 59.6 |
| 26 | Tai Lavatai | Navy | SO | QB | 2 | 51 | 84 | 43 | 135 | 3.14 | 67.5 |
| 27 | James Harris II | Navy | SR | FB | 2 | 56 | 0 | 18 | 56 | 3.11 | 28.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 9.0 plays per game played.