2021 American Athletic Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Coby Bryant | Cincinnati | SR | CB | 5 | 3 | 95 | 1 | 0.60 |
| 2 | Antonio Grier | S Florida | SR | LB | 4 | 2 | 69 | 1 | 0.50 |
| 2 | Dwayne Boyles | S Florida | SR | LB | 4 | 2 | 4 | 0 | 0.50 |
| 2 | Deshawn Pace | Cincinnati | SO | LB | 5 | 2 | 31 | 0 | 0.40 |
| 5 | Jalen Ware | Temple | JR | SAF | 3 | 1 | -7 | 0 | 0.33 |
| 5 | Gervarrius Owens | Houston | JR | S | 4 | 1 | 45 | 1 | 0.25 |
| 5 | Travon Fuller | Tulsa | SR | CB | 4 | 1 | 44 | 0 | 0.25 |
| 5 | Shawn Dourseau | ECU | SO | SAF | 4 | 1 | 33 | 0 | 0.25 |
| 5 | Macon Clark | Tulane | JR | S | 4 | 1 | 33 | 0 | 0.25 |
| 5 | Malik Fleming | ECU | SO | CB | 4 | 1 | 31 | 1 | 0.25 |
| 5 | Warren Saba | ECU | SR | SAF | 4 | 1 | 31 | 0 | 0.25 |
| 5 | Teagan Wilk | ECU | FR | SAF | 4 | 1 | 6 | 0 | 0.25 |
| 5 | Juan Powell | ECU | FR | SAF | 4 | 1 | 4 | 0 | 0.25 |
| 5 | Arquon Bush | Cincinnati | JR | CB | 4 | 1 | 1 | 0 | 0.25 |
| 5 | Jamal Glenn | Navy | SR | CB | 4 | 1 | 1 | 0 | 0.25 |
| 5 | Jireh Wilson | ECU | SO | SAF | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Alex Hogan | Houston | JR | CB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Marcus Jones | Houston | SR | CB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Damarion Williams | Houston | SR | CB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Tyrez Lindsey | Memphis | SR | DB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Mekhi LaPointe | S Florida | SR | DB | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Jaise Oliver | Tulsa | SO | S | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Bryson Powers | Tulsa | SR | S | 4 | 1 | 0 | 0 | 0.25 |
| 5 | Ja'Quan McMillian | ECU | SO | CB | 4 | 1 | -3 | 0 | 0.25 |
| 5 | Isaac Slade-Matautia | SMU | JR | LB | 4 | 1 | -8 | 0 | 0.25 |
| 5 | Dyllon Lester | UCF | JR | DB | 5 | 1 | 34 | 0 | 0.20 |
| 5 | Divaad Wilson | UCF | JR | DB | 5 | 1 | 25 | 0 | 0.20 |
| 5 | Davonte Brown | UCF | SO | DB | 5 | 1 | 14 | 0 | 0.20 |
| 5 | Jeremiah Jean-Baptiste | UCF | JR | LB | 5 | 1 | 8 | 0 | 0.20 |
| 5 | Ja'von Hicks | Cincinnati | SR | S | 5 | 1 | 7 | 0 | 0.20 |
| 5 | Ahmad Gardner | Cincinnati | JR | CB | 5 | 1 | 4 | 0 | 0.20 |
| 5 | Diego Fagot | Navy | SR | LB | 5 | 1 | 0 | 0 | 0.20 |
| 5 | Taylor Robinson | Navy | JR | BAN | 5 | 1 | 0 | 0 | 0.20 |
| 5 | Johnny Hodges | Navy | JR | LB | 5 | 1 | 0 | 0 | 0.20 |
| 5 | Rayuan Lane | Navy | FR | S | 5 | 1 | 0 | 0 | 0.20 |