2021 American Athletic Conference Leaders Sacks - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Cincinnati | 9 | 31.0 | 188 | 3.44 |
| 2 | UCF | 8 | 28.0 | 188 | 3.50 |
| 3 | Houston | 9 | 25.0 | 159 | 2.78 |
| 4 | Tulane | 8 | 23.0 | 127 | 2.88 |
| 5 | Memphis | 8 | 21.0 | 137 | 2.63 |
| 6 | SMU | 8 | 19.0 | 120 | 2.38 |
| 7 | East Carolina | 8 | 16.0 | 115 | 2.00 |
| 8 | Tulsa | 8 | 14.0 | 68 | 1.75 |
| 9 | Navy | 8 | 11.0 | 78 | 1.38 |
| 10 | Temple | 8 | 9.0 | 62 | 1.13 |
| 11 | South Florida | 8 | 6.0 | 36 | 0.75 |