2021 American Athletic Conference Leaders Sacks - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Houston | 13 | 40.0 | 256 | 3.08 |
| 2 | Cincinnati | 13 | 38.0 | 228 | 2.92 |
| 3 | UCF | 12 | 36.0 | 233 | 3.00 |
| 4 | Tulane | 11 | 29.0 | 182 | 2.64 |
| 5 | Memphis | 11 | 27.0 | 188 | 2.46 |
| 6 | Tulsa | 12 | 25.0 | 131 | 2.08 |
| 7 | SMU | 11 | 24.0 | 146 | 2.18 |
| 8 | East Carolina | 11 | 21.0 | 153 | 1.91 |
| 9 | Navy | 12 | 16.0 | 111 | 1.33 |
| 10 | Temple | 11 | 13.0 | 94 | 1.18 |
| 11 | South Florida | 11 | 8.0 | 51 | 0.73 |