2021 American Athletic Conference Leaders Passes Defended - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Houston | 8 | 10 | 27 | 37 | 4.63 |
| 2 | Cincinnati | 5 | 9 | 12 | 21 | 4.20 |
| 3 | UCF | 8 | 7 | 40 | 47 | 5.88 |
| 3 | East Carolina | 5 | 7 | 22 | 29 | 5.80 |
| 5 | Tulsa | 7 | 5 | 29 | 34 | 4.86 |
| 5 | SMU | 7 | 5 | 17 | 22 | 3.14 |
| 5 | South Florida | 3 | 5 | 4 | 9 | 3.00 |
| 8 | Memphis | 4 | 2 | 18 | 20 | 5.00 |
| 8 | Temple | 6 | 2 | 11 | 13 | 2.17 |
| 10 | Tulane | 2 | 1 | 7 | 8 | 4.00 |
| 10 | Navy | 2 | 1 | 2 | 3 | 1.50 |