2021 American Athletic Conference Leaders Passes Defended - Games in October Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 5 | 8 | 15 | 23 | 4.60 |
| 2 | East Carolina | 4 | 7 | 13 | 20 | 5.00 |
| 3 | South Florida | 4 | 5 | 12 | 17 | 4.25 |
| 3 | Navy | 5 | 5 | 10 | 15 | 3.00 |
| 5 | UCF | 5 | 4 | 19 | 23 | 4.60 |
| 5 | Houston | 4 | 4 | 12 | 16 | 4.00 |
| 7 | Tulsa | 4 | 3 | 13 | 16 | 4.00 |
| 8 | Tulane | 4 | 1 | 14 | 15 | 3.75 |
| 8 | SMU | 4 | 1 | 10 | 11 | 2.75 |
| 8 | Temple | 4 | 1 | 9 | 10 | 2.50 |
| 8 | Memphis | 4 | 1 | 7 | 8 | 2.00 |