2021 Big Ten Conference Leaders Long All Purpose Plays - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Blake Corum | Michigan | SO | RB | 2 | 3 | 2 | 2 | 1 | 1 | 0 | 0 |
| 1 | TreVeyon Henderson | Ohio State | FR | RB | 2 | 5 | 3 | 2 | 0 | 0 | 0 | 0 |
| 1 | Samori Toure | Nebraska | SR | WR | 1 | 2 | 2 | 2 | 2 | 0 | 0 | 0 |
| 4 | Daylen Baldwin | Michigan | SR | WR | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | David Bell | Purdue | JR | WR | 2 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| 4 | Ronnie Bell | Michigan | SR | WR | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Chase Brown | Illinois | SO | RB | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Aron Cruickshank | Rutgers | JR | WR | 1 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 4 | Dontay Demus Jr. | Maryland | SR | WR | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Donovan Edwards | Michigan | FR | RB | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 4 | Emeka Egbuka | Ohio State | FR | WR | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Isaac Guerendo | Wisconsin | JR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | A.J. Henning | Michigan | SO | WR | 2 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Chris Hickman | Nebraska | FR | TE | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 4 | Evan Hull | N'western | SO | RB | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 4 | Cornelius Johnson | Michigan | JR | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 4 | Adrian Martinez | Nebraska | JR | QB | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 4 | Cameron Martinez | Ohio State | FR | SAF | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Chez Mellusi | Wisconsin | JR | RB | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 4 | Trey Potts | Minnesota | SO | RB | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 4 | Jayden Reed | Mich St | JR | WR | 1 | 4 | 3 | 1 | 1 | 1 | 1 | 0 |
| 4 | Garrett Wilson | Ohio State | JR | WR | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |