2021 Big Ten Conference Leaders Scoring Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ohio State | 4 | 18 | 1 | 18 | 0 | 0 | 129 | 32.3 |
| 2 | Iowa | 2 | 8 | 2 | 8 | 0 | 0 | 62 | 31.0 |
| 3 | Purdue | 4 | 16 | 3 | 15 | 1 | 0 | 122 | 30.5 |
| 3 | Minnesota | 2 | 9 | 3 | 9 | 0 | 0 | 72 | 36.0 |
| 5 | Northwestern | 3 | 11 | 4 | 10 | 0 | 0 | 88 | 29.3 |
| 5 | Illinois | 1 | 3 | 4 | 3 | 0 | 0 | 33 | 33.0 |
| 5 | Michigan State | 3 | 14 | 4 | 14 | 0 | 0 | 110 | 36.7 |
| 8 | Michigan | 4 | 12 | 5 | 10 | 2 | 0 | 101 | 25.3 |
| 8 | Wisconsin | 3 | 10 | 5 | 9 | 1 | 0 | 86 | 28.7 |
| 8 | Maryland | 4 | 29 | 5 | 27 | 0 | 0 | 216 | 54.0 |
| 11 | Rutgers | 4 | 17 | 7 | 16 | 1 | 0 | 141 | 35.3 |
| 12 | Penn State | 5 | 15 | 9 | 14 | 0 | 0 | 131 | 26.2 |
| 12 | Indiana | 5 | 21 | 9 | 18 | 1 | 1 | 175 | 35.0 |
| 14 | Nebraska | 5 | 12 | 15 | 11 | 1 | 1 | 132 | 26.4 |