2021 Big Ten Conference Leaders Interceptions - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Ohio State | 2 | 4 | 150 | 2 | 2.00 |
| 1 | Rutgers | 1 | 2 | 67 | 1 | 2.00 |
| 1 | Northwestern | 1 | 2 | 26 | 0 | 2.00 |
| 1 | Penn State | 1 | 2 | 15 | 1 | 2.00 |
| 5 | Minnesota | 2 | 2 | 28 | 0 | 1.00 |
| 5 | Nebraska | 1 | 1 | 22 | 0 | 1.00 |
| 7 | Michigan | 2 | 1 | 27 | 0 | 0.50 |
| 7 | Illinois | 2 | 1 | 2 | 0 | 0.50 |
| 7 | Indiana | 2 | 1 | 0 | 0 | 0.50 |
| 7 | Purdue | 2 | 1 | 0 | 0 | 0.50 |
| 11 | Wisconsin | 3 | 1 | 6 | 0 | 0.33 |