2021 Mid-American Conference Leaders Passing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 11 | 270 | 139 | 51.5 | 1792 | 6.6 | 14 | 3 | 122.12 | 24.5 | 162.9 |
| 2 | Toledo | 12 | 372 | 204 | 54.8 | 2266 | 6.1 | 14 | 7 | 114.66 | 31.0 | 188.8 |
| 3 | Bowling Green | 12 | 308 | 180 | 58.4 | 2234 | 7.3 | 15 | 12 | 127.65 | 25.7 | 186.2 |
| 4 | Eastern Michigan | 13 | 394 | 231 | 58.6 | 3070 | 7.8 | 19 | 8 | 135.93 | 30.3 | 236.2 |
| 5 | Northern Illinois | 13 | 391 | 234 | 59.8 | 3099 | 7.9 | 26 | 3 | 146.85 | 30.1 | 238.4 |
| 6 | Miami (Ohio) | 12 | 357 | 215 | 60.2 | 2598 | 7.3 | 17 | 7 | 133.14 | 29.8 | 216.5 |
| 7 | Central Michigan | 13 | 426 | 261 | 61.3 | 3422 | 8.0 | 22 | 5 | 143.44 | 32.8 | 263.2 |
| 8 | Buffalo | 12 | 298 | 183 | 61.4 | 2651 | 8.9 | 20 | 3 | 156.28 | 24.8 | 220.9 |
| 9 | Kent State | 13 | 450 | 282 | 62.7 | 3512 | 7.8 | 22 | 16 | 137.24 | 34.6 | 270.2 |
| 10 | Ball State | 13 | 398 | 263 | 66.1 | 3110 | 7.8 | 17 | 15 | 138.27 | 30.6 | 239.2 |
| 11 | Akron | 11 | 275 | 183 | 66.5 | 2237 | 8.1 | 24 | 5 | 160.04 | 25.0 | 203.4 |
| 12 | Ohio | 11 | 353 | 236 | 66.9 | 2619 | 7.4 | 15 | 5 | 140.37 | 32.1 | 238.1 |