2021 Mid-American Conference Leaders Opponent First Downs - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 11 | 83 | 76 | 17 | 176 | 16.0 |
| 2 | Toledo | 12 | 92 | 108 | 29 | 229 | 19.1 |
| 3 | Miami (Ohio) | 12 | 88 | 125 | 19 | 232 | 19.3 |
| 4 | Central Michigan | 13 | 102 | 130 | 23 | 255 | 19.6 |
| 5 | Buffalo | 12 | 125 | 97 | 23 | 245 | 20.4 |
| 6 | Bowling Green | 12 | 135 | 94 | 26 | 255 | 21.3 |
| 7 | Northern Illinois | 13 | 140 | 128 | 13 | 281 | 21.6 |
| 8 | Ball State | 13 | 130 | 140 | 18 | 288 | 22.2 |
| 9 | Eastern Michigan | 13 | 144 | 133 | 19 | 296 | 22.8 |
| 10 | Ohio | 11 | 103 | 129 | 24 | 256 | 23.3 |
| 11 | Akron | 11 | 142 | 103 | 15 | 260 | 23.6 |
| 12 | Kent State | 13 | 148 | 163 | 32 | 343 | 26.4 |