2021 Mid-American Conference Leaders Rushing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 4 | 142 | 467 | 3.29 | 7 | 35.50 | 116.75 |
| 2 | Kent State | 4 | 156 | 573 | 3.67 | 9 | 39.00 | 143.25 |
| 3 | Toledo | 4 | 159 | 641 | 4.03 | 5 | 39.75 | 160.25 |
| 4 | Ohio | 4 | 125 | 520 | 4.16 | 6 | 31.25 | 130.00 |
| 5 | Miami (Ohio) | 4 | 157 | 696 | 4.43 | 8 | 39.25 | 174.00 |
| 6 | Buffalo | 3 | 117 | 547 | 4.68 | 7 | 39.00 | 182.33 |
| 7 | Bowling Green | 3 | 107 | 508 | 4.75 | 8 | 35.67 | 169.33 |
| 8 | Ball State | 4 | 157 | 771 | 4.91 | 6 | 39.25 | 192.75 |
| 9 | Eastern Michigan | 4 | 162 | 890 | 5.49 | 7 | 40.50 | 222.50 |
| 10 | Western Michigan | 4 | 132 | 755 | 5.72 | 6 | 33.00 | 188.75 |
| 11 | Northern Illinois | 4 | 179 | 1126 | 6.29 | 10 | 44.75 | 281.50 |
| 12 | Akron | 4 | 181 | 1247 | 6.89 | 11 | 45.25 | 311.75 |