2021 Mid-American Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Northern Illinois | 11 | 119 | 113 | 11 | 243 | 22.1 |
| 2 | Akron | 9 | 126 | 80 | 12 | 218 | 24.2 |
| 3 | Central Michigan | 9 | 84 | 94 | 14 | 192 | 21.3 |
| 4 | Bowling Green | 9 | 97 | 80 | 16 | 193 | 21.4 |
| 4 | Ball State | 11 | 112 | 111 | 16 | 239 | 21.7 |
| 4 | Ohio | 9 | 83 | 121 | 16 | 220 | 24.4 |
| 7 | Western Michigan | 10 | 79 | 76 | 17 | 172 | 17.2 |
| 7 | Eastern Michigan | 11 | 126 | 115 | 17 | 258 | 23.5 |
| 9 | Buffalo | 10 | 114 | 86 | 19 | 219 | 21.9 |
| 10 | Miami (Ohio) | 11 | 87 | 119 | 21 | 227 | 20.6 |
| 11 | Kent State | 10 | 116 | 128 | 26 | 270 | 27.0 |
| 12 | Toledo | 12 | 96 | 115 | 30 | 241 | 20.1 |