2021 National Leaders Long All Purpose Plays - Games vs. FBS Teams With Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Brian Battie | S Florida | SO | RB | 8 | 4 | 3 | 3 | 3 | 3 | 3 | 3 |
| 2 | Brian Brewton | UConn | FR | RB | 8 | 4 | 4 | 3 | 3 | 3 | 2 | 2 |
| 2 | Marcus Jones | Houston | SR | CB | 5 | 3 | 3 | 2 | 2 | 2 | 2 | 2 |
| 2 | Malik Knowles | Kansas St | JR | WR | 6 | 5 | 3 | 2 | 2 | 2 | 2 | 2 |
| 5 | Kris Abrams-Draine | Missouri | SO | DB | 8 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Devon Achane | Texas A&M | SO | RB | 5 | 6 | 2 | 1 | 1 | 1 | 1 | 1 |
| 5 | Carlinos Acie | Navy | SR | SB | 10 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
| 5 | Rasheen Ali | Marshall | FR | RB | 6 | 4 | 3 | 2 | 2 | 1 | 1 | 1 |
| 5 | Andrel Anthony | Michigan | FR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Calvin Austin III | Memphis | SR | WR | 7 | 5 | 3 | 2 | 2 | 1 | 1 | 1 |
| 5 | Reed Blankenship | MTSU | SR | S | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | LD Brown | Okla St | SR | RB | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Jordan Byrd | SDSU | SR | RB | 7 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| 5 | David Carter Jr. | EMU | FR | DB | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Britain Covey | Utah | JR | WR | 9 | 6 | 3 | 3 | 3 | 3 | 2 | 1 |
| 5 | Trestan Ebner | Baylor | SR | RB | 8 | 6 | 3 | 2 | 2 | 1 | 1 | 1 |
| 5 | Lideatrick Griffin | Miss St | SO | WR | 6 | 4 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Justin Hall | Ball State | SR | WR | 8 | 8 | 2 | 2 | 2 | 2 | 1 | 1 |
| 5 | Maquel Haywood | Navy | FR | SB | 6 | 4 | 2 | 1 | 1 | 1 | 1 | 1 |
| 5 | LaMareon James | ODU | FR | CB | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Jawhar Jordan | Louisville | FR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Zonovan Knight | NC State | SO | RB | 4 | 2 | 2 | 2 | 2 | 2 | 1 | 1 |
| 5 | Alan Lamar | Ark St | SR | RB | 5 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Matt Landers | Toledo | JR | WR | 6 | 2 | 2 | 2 | 2 | 2 | 2 | 1 |
| 5 | Tyric LeBeauf | Boise St | JR | CB | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Marion Lukes | CMU | FR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Bryan Massey | SMU | SO | S | 4 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Michael Mathison | Akron | SO | WR | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Kalil Pimpleton | CMU | JR | WR | 6 | 8 | 7 | 4 | 3 | 3 | 1 | 1 |
| 5 | Brennan Presley | Okla St | SO | WR | 9 | 6 | 4 | 1 | 1 | 1 | 1 | 1 |
| 5 | Clint Ratkovich | N Illinois | SR | RB | 7 | 2 | 2 | 2 | 1 | 1 | 1 | 1 |
| 5 | Nikko Reed | Colorado | FR | CB | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Ainias Smith | Texas A&M | JR | WR | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Jaylen Stinson | Duke | SO | S | 3 | 3 | 2 | 2 | 2 | 2 | 2 | 1 |
| 5 | Cameron Stone | Wyoming | SO | CB | 5 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Jacquez Stuart | Toledo | FR | RB | 6 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Titus Swen | Wyoming | JR | RB | 5 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 5 | Sean Tyler | W Mich | SO | RB | 7 | 3 | 2 | 2 | 2 | 2 | 1 | 1 |
| 5 | Chris Tyree | Notre Dame | SO | RB | 5 | 4 | 3 | 3 | 1 | 1 | 1 | 1 |
| 5 | Jalen Virgil | App St | SR | WR | 6 | 8 | 3 | 2 | 2 | 1 | 1 | 1 |
| 5 | Al Walcott | Baylor | JR | CB | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 5 | Jameson Williams | Alabama | JR | WR | 9 | 11 | 9 | 6 | 5 | 3 | 1 | 1 |
| 5 | Winston Wright Jr. | WVU | JR | WR | 8 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |