2021 National Leaders Long All Purpose Plays - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | LaMareon James | ODU | FR | CB | 12 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| 1 | Marcus Jones | Houston | SR | CB | 12 | 8 | 8 | 3 | 3 | 3 | 2 | 2 |
| 1 | Alan Lamar | Ark St | SR | RB | 11 | 10 | 3 | 3 | 2 | 2 | 2 | 2 |
| 1 | Sean Tyler | W Mich | SO | RB | 11 | 7 | 4 | 4 | 4 | 3 | 2 | 2 |
| 1 | Jalen Virgil | App St | SR | WR | 10 | 10 | 6 | 3 | 3 | 2 | 2 | 2 |
| 1 | Jameson Williams | Alabama | JR | WR | 10 | 14 | 9 | 8 | 6 | 5 | 4 | 2 |
| 1 | Winston Wright Jr. | WVU | JR | WR | 10 | 5 | 4 | 2 | 2 | 2 | 2 | 2 |
| 8 | Israel Abanikanda | Pittsburgh | SO | RB | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Kris Abrams-Draine | Missouri | SO | DB | 10 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Carlinos Acie | Navy | SR | SB | 9 | 2 | 2 | 2 | 2 | 1 | 1 | 1 |
| 8 | Tyrell Ajian | Kentucky | SR | DB | 11 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Rasheen Ali | Marshall | FR | RB | 12 | 5 | 5 | 3 | 1 | 1 | 1 | 1 |
| 8 | Kazmeir Allen | UCLA | JR | RB | 10 | 8 | 6 | 4 | 3 | 2 | 1 | 1 |
| 8 | Calvin Austin III | Memphis | SR | WR | 11 | 9 | 7 | 6 | 4 | 2 | 1 | 1 |
| 8 | Brian Battie | S Florida | SO | RB | 8 | 3 | 3 | 1 | 1 | 1 | 1 | 1 |
| 8 | Reed Blankenship | MTSU | SR | S | 13 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Zion Bowens | Hawai'i | SR | WR | 10 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Stephan Bracey | Wisconsin | SO | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Brian Brewton | UConn | FR | RB | 9 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | LD Brown | Okla St | SR | RB | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Treylon Burks | Arkansas | JR | WR | 9 | 7 | 5 | 3 | 2 | 2 | 2 | 1 |
| 8 | David Carter Jr. | EMU | FR | DB | 13 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Grayson Cash | UAB | JR | S | 11 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Tyrese Chambers | FIU | SO | WR | 12 | 15 | 10 | 6 | 5 | 2 | 1 | 1 |
| 8 | Trey Cobb | App St | SR | ILB | 12 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Haaziq Daniels | Air Force | JR | QB | 10 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Derius Davis | TCU | SR | WR | 9 | 8 | 6 | 2 | 2 | 2 | 1 | 1 |
| 8 | Trestan Ebner | Baylor | SR | RB | 9 | 10 | 6 | 4 | 2 | 1 | 1 | 1 |
| 8 | Tiyon Evans | Tennessee | JR | RB | 5 | 3 | 3 | 1 | 1 | 1 | 1 | 1 |
| 8 | Jahmyr Gibbs | Ga Tech | FR | RB | 8 | 9 | 6 | 5 | 4 | 3 | 1 | 1 |
| 8 | Justin Hall | Ball State | SR | WR | 11 | 10 | 4 | 2 | 2 | 2 | 1 | 1 |
| 8 | Camron Harrell | USM | JR | DB | 11 | 6 | 2 | 2 | 2 | 1 | 1 | 1 |
| 8 | Tyler Harrell | Louisville | SO | WR | 8 | 7 | 2 | 2 | 1 | 1 | 1 | 1 |
| 8 | Jayden Harrison | Marshall | SO | WR | 12 | 4 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Maquel Haywood | Navy | FR | SB | 6 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Ta'Zhawn Henry | Houston | JR | RB | 12 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Alex Hogan | Houston | JR | CB | 13 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Ahmari Huggins-Bruce | Louisville | FR | WR | 7 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Evan Hull | N'western | SO | RB | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Jarquez Hunter | Auburn | FR | RB | 8 | 4 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Montrell Johnson | La-Lafytte | FR | RB | 14 | 3 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Charlie Jones | Iowa | SR | WR | 12 | 10 | 4 | 2 | 2 | 2 | 1 | 1 |
| 8 | Velus Jones Jr. | Tennessee | SR | WR | 8 | 9 | 4 | 2 | 1 | 1 | 1 | 1 |
| 8 | Jawhar Jordan | Louisville | FR | RB | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Zonovan Knight | NC State | SO | RB | 10 | 4 | 3 | 1 | 1 | 1 | 1 | 1 |
| 8 | Matt Landers | Toledo | JR | WR | 11 | 5 | 4 | 3 | 3 | 3 | 3 | 1 |
| 8 | Tyric LeBeauf | Boise St | JR | CB | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Travis Levy | BC | SR | RB | 9 | 3 | 2 | 2 | 2 | 1 | 1 | 1 |
| 8 | Brandon Lewis | Air Force | SR | WR | 11 | 9 | 6 | 4 | 3 | 1 | 1 | 1 |
| 8 | Isaiah Likely | Coast Car | SR | TE | 13 | 6 | 3 | 2 | 2 | 1 | 1 | 1 |
| 8 | Marion Lukes | CMU | FR | RB | 13 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Bryan Massey | SMU | SO | S | 10 | 7 | 4 | 2 | 1 | 1 | 1 | 1 |
| 8 | Michael Mathison | Akron | SO | WR | 10 | 7 | 2 | 2 | 1 | 1 | 1 | 1 |
| 8 | Kalil Pimpleton | CMU | JR | WR | 13 | 11 | 7 | 4 | 3 | 3 | 1 | 1 |
| 8 | TJ Pledger | Utah | JR | RB | 9 | 5 | 3 | 2 | 1 | 1 | 1 | 1 |
| 8 | Clint Ratkovich | N Illinois | SR | RB | 13 | 2 | 2 | 2 | 1 | 1 | 1 | 1 |
| 8 | Nikko Remigio | California | SR | WR | 10 | 4 | 3 | 3 | 2 | 1 | 1 | 1 |
| 8 | Armani Rogers | Ohio | SR | QB | 11 | 2 | 2 | 2 | 1 | 1 | 1 | 1 |
| 8 | T.D. Roof | App St | SR | ILB | 11 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Trayvon Rudolph | N Illinois | FR | WR | 13 | 16 | 7 | 4 | 4 | 4 | 1 | 1 |
| 8 | Savon Scarver | Utah State | SR | WR | 12 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Ainias Smith | Texas A&M | JR | WR | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Tarheeb Still | Maryland | SO | DB | 9 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Jaylen Stinson | Duke | SO | S | 10 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Jacquez Stuart | Toledo | FR | RB | 12 | 4 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Ja'Sir Taylor | Wk Forest | SR | DB | 11 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Tre Tucker | Cincinnati | JR | WR | 11 | 4 | 2 | 1 | 1 | 1 | 1 | 1 |
| 8 | Chris Tyree | Notre Dame | SO | RB | 10 | 4 | 3 | 3 | 1 | 1 | 1 | 1 |
| 8 | Kenneth Walker III | Mich St | JR | RB | 10 | 7 | 3 | 3 | 2 | 2 | 1 | 1 |
| 8 | Anthony Watkins | Tulsa | SO | RB | 9 | 7 | 5 | 3 | 3 | 3 | 1 | 1 |
| 8 | Ja'Cquez Williams | La-Monroe | SR | LB | 10 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Kyren Williams | Notre Dame | SO | RB | 11 | 7 | 5 | 3 | 1 | 1 | 1 | 1 |
| 8 | JT Woods | Baylor | SR | S | 9 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |