2021 National Leaders Passes Defended - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Greg Rubin | Memphis | FR | DB | 4 | 0 | 10 | 10 | 2.50 |
| 2 | Ja'Quan McMillian | ECU | SO | CB | 4 | 3 | 9 | 12 | 3.00 |
| 3 | Devon Witherspoon | Illinois | SO | DB | 4 | 0 | 7 | 7 | 1.75 |
| 3 | A.J. Hampton, Jr. | N'western | JR | DB | 4 | 0 | 7 | 7 | 1.75 |
| 3 | Cortez Davis | Hawai'i | SR | DB | 5 | 0 | 7 | 7 | 1.40 |
| 6 | Caelen Carson | Wk Forest | FR | DB | 4 | 2 | 6 | 8 | 2.00 |
| 6 | Jakorian Bennett | Maryland | SR | DB | 4 | 2 | 6 | 8 | 2.00 |
| 6 | Rishard Dames | FIU | JR | DB | 4 | 1 | 6 | 7 | 1.75 |
| 6 | Malik Shorts | USM | SO | DB | 4 | 1 | 6 | 7 | 1.75 |
| 6 | Rejzohn Wright | Oregon St | JR | DB | 4 | 1 | 6 | 7 | 1.75 |
| 6 | Denzel Burke | Ohio State | FR | CB | 4 | 0 | 6 | 6 | 1.50 |
| 6 | Yusuf Corker | Kentucky | SR | DB | 4 | 0 | 6 | 6 | 1.50 |
| 6 | Nick Grant | Virginia | SR | CB | 4 | 0 | 6 | 6 | 1.50 |
| 6 | Jordan Gandy | N Illinois | SO | CB | 4 | 0 | 6 | 6 | 1.50 |
| 15 | Arquon Bush | Cincinnati | JR | CB | 3 | 2 | 5 | 7 | 2.33 |
| 15 | Cameron Brown | Ohio State | JR | CB | 2 | 0 | 5 | 5 | 2.50 |
| 15 | Darrell Luter Jr. | USA | JR | CB | 3 | 0 | 5 | 5 | 1.67 |
| 15 | Donte Martin | New Mexico | JR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 15 | Theo Jackson | Tennessee | SR | DB | 4 | 0 | 5 | 5 | 1.25 |
| 15 | Collin Gamble | California | SO | CB | 4 | 0 | 5 | 5 | 1.25 |
| 15 | C.J. Coldon | Wyoming | JR | CB | 4 | 0 | 5 | 5 | 1.25 |
| 15 | Kitan Oladapo | Oregon St | SO | DB | 4 | 0 | 5 | 5 | 1.25 |
| 23 | Corvan Taylor | Air Force | SR | SS | 4 | 3 | 4 | 7 | 1.75 |
| 23 | Max Melton | Rutgers | FR | DB | 3 | 2 | 4 | 6 | 2.00 |
| 23 | Kyu Blu Kelly | Stanford | JR | CB | 4 | 2 | 4 | 6 | 1.50 |
| 23 | Travon Fuller | Tulsa | SR | CB | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Devin Taylor | BGSU | SR | CB | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Angelo Grose | Mich St | SO | S | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Lewis Cine | Georgia | JR | DB | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Dorian Jackson | W Mich | JR | CB | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Teldrick Ross | MTSU | SO | S | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Lummie Young IV | Duke | SR | S | 4 | 1 | 4 | 5 | 1.25 |
| 23 | Levelle Bailey | Fresno St | JR | LB | 5 | 1 | 4 | 5 | 1.00 |
| 23 | Cameron Lockridge | Hawai'i | JR | DB | 5 | 1 | 4 | 5 | 1.00 |
| 23 | Faion Hicks | Wisconsin | SR | CB | 2 | 0 | 4 | 4 | 2.00 |
| 23 | Jordan Wright | Kentucky | SR | OLB | 3 | 0 | 4 | 4 | 1.33 |
| 23 | Nehemiah Shelton | SJSU | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Bobby Brown, II | SJSU | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Davon Ferguson | BGSU | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Tony Grimes | N Carolina | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Kenny Logan Jr. | Kansas | JR | S | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Daevion Davis | Vanderbilt | JR | DL | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Taylon Doss | Ark St | FR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Noah Boykin | U Mass | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Josh Wallace | U Mass | SO | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | D.C. Williams | Texas St | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Antonio Johnson | Texas A&M | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | DaMarcus Fields | Texas Tech | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Rayshad Williams | Texas Tech | JR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Rodney Owens | Memphis | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Quindell Johnson | Memphis | JR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Dishon McNary | CMU | JR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Vincent Gray | Michigan | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Brad Hawkins | Michigan | SR | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Jarrick Bernard-Converse | Okla St | SR | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Cam Smith | S Carolina | SO | DB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Noah Tumblin | SDSU | SO | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Bryquice Brown | Georgia St | SO | CB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Jamal Hines | Toledo | JR | OLB | 4 | 0 | 4 | 4 | 1.00 |
| 23 | Bralyn Lux | Fresno St | SO | DB | 5 | 0 | 4 | 4 | 0.80 |
| 23 | Elijah Gates | Fresno St | SR | DB | 5 | 0 | 4 | 4 | 0.80 |
| 23 | Khoury Bethley | Hawai'i | SR | DB | 5 | 0 | 4 | 4 | 0.80 |
| 23 | Jartavius Martin | Illinois | JR | DB | 5 | 0 | 4 | 4 | 0.80 |
| 64 | Elvis Hines | Kent State | SR | CB | 4 | 3 | 3 | 6 | 1.50 |
| 64 | Syrus Dumas | NMSU | SO | DB | 2 | 2 | 3 | 5 | 2.50 |
| 64 | Tavian Combs | New Mexico | SO | S | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Seyi Oladipo | Boise St | FR | S | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Tyreque Jones | Boise St | SR | S | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Jalen Catalon | Arkansas | SO | DB | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Ji'Ayir Brown | Penn State | SR | S | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Riley Moss | Iowa | SR | DB | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Nick Cross | Maryland | JR | DB | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Marquel Broughton | Army | JR | DB | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Cam Hart | Notre Dame | SO | CB | 4 | 2 | 3 | 5 | 1.25 |
| 64 | Dyllon Lester | UCF | JR | DB | 3 | 1 | 3 | 4 | 1.33 |
| 64 | Kaiir Elam | Florida | JR | CB | 3 | 1 | 3 | 4 | 1.33 |
| 64 | Jimmy Wyrick | Stanford | FR | CB | 3 | 1 | 3 | 4 | 1.33 |
| 64 | Myles Bell | UConn | SO | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Tanner Ingle | NC State | JR | SAF | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Nic Jones | Ball State | JR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Cameron Martinez | Ohio State | FR | SAF | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Jerrick Reed II | New Mexico | SR | S | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Warren Saba | ECU | SR | SAF | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Jaylen McCollough | Tennessee | JR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Jacquez Jones | Kentucky | SR | ILB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Ethan Barr | Vanderbilt | SO | LB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Jalen Green | Miss St | SR | S | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Trey Baldwin | La Tech | SR | LB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Jarius Reimonenq | Ark St | SO | S | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Leon Jones | Ark St | SO | CB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Darian Chestnut | Syracuse | FR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Micah Abraham | Marshall | SO | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Kelee Ringo | Georgia | FR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Jayden Peevy | Texas A&M | SR | DL | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Zyon Gilbert | FAU | SR | CB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Kris Abrams-Draine | Missouri | SO | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Bryan Massey | SMU | SO | S | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Alex Austin | Oregon St | FR | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Alton Julian | Oregon St | SO | DB | 4 | 1 | 3 | 4 | 1.00 |
| 64 | Patrick McMorris | SDSU | JR | S | 4 | 1 | 3 | 4 | 1.00 |