2022 Big 12 Conference Leaders Long All Purpose Plays - Games at Home Only through 01/09/2023
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Malik Knowles | Kansas St | SR | WR | 7 | 3 | 3 | 3 | 3 | 1 | 0 | 0 |
| 1 | Deuce Vaughn | Kansas St | JR | RB | 7 | 5 | 3 | 3 | 3 | 1 | 1 | 0 |
| 3 | Monaray Baldwin | Baylor | SO | WR | 5 | 5 | 5 | 3 | 2 | 2 | 0 | 0 |
| 3 | Derius Davis | TCU | SR | WR | 6 | 2 | 2 | 2 | 2 | 1 | 1 | 0 |
| 5 | Taye Barber | TCU | SR | WR | 6 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Jason Bean | Kansas | SR | QB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Jirehl Brock | Iowa State | JR | RB | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Phillip Brooks | Kansas St | SR | WR | 7 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Jordan Brown | Texas Tech | SO | WR | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Cobee Bryant | Kansas | SO | CB | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Jasir Cox | WVU | SR | SPR | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Emari Demercado | TCU | SR | RB | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | CJ Donaldson Jr. | WVU | FR | RB | 3 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 5 | Max Duggan | TCU | SR | QB | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Bryce Ford-Wheaton | WVU | JR | WR | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Gunnar Henderson | TCU | SR | WR | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Daniel Hishaw Jr. | Kansas | SO | RB | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Gavin Holmes | Baylor | SR | WR | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 5 | Sam James | WVU | JR | WR | 6 | 7 | 4 | 3 | 1 | 1 | 0 | 0 |
| 5 | D'Shawn Jamison | Texas | SR | DB | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 5 | Adrian Martinez | Kansas St | SR | QB | 5 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 5 | Kendre Miller | TCU | JR | RB | 6 | 3 | 3 | 2 | 1 | 0 | 0 | 0 |
| 5 | Marvin Mims Jr. | Oklahoma | JR | WR | 6 | 11 | 5 | 3 | 1 | 0 | 0 | 0 |
| 5 | Devin Neal | Kansas | SO | RB | 6 | 6 | 3 | 2 | 1 | 1 | 1 | 0 |
| 5 | John Paul Richardson | Okla St | SO | WR | 7 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 5 | Bijan Robinson | Texas | JR | RB | 7 | 4 | 3 | 1 | 1 | 1 | 0 | 0 |