2022 Big 12 Conference Leaders Long All Purpose Plays - Games vs. FBS Teams With Winning Record Only through 01/09/2023
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Derius Davis | TCU | SR | WR | 8 | 8 | 5 | 5 | 4 | 2 | 2 | 0 |
| 2 | Deuce Vaughn | Kansas St | JR | RB | 7 | 5 | 5 | 3 | 3 | 1 | 1 | 0 |
| 3 | Monaray Baldwin | Baylor | SO | WR | 6 | 3 | 3 | 2 | 2 | 2 | 0 | 0 |
| 3 | Emari Demercado | TCU | SR | RB | 8 | 2 | 2 | 2 | 2 | 0 | 0 | 0 |
| 3 | Bijan Robinson | Texas | JR | RB | 6 | 9 | 7 | 2 | 2 | 1 | 0 | 0 |
| 6 | Lawrence Arnold | Kansas | SO | WR | 8 | 5 | 2 | 1 | 1 | 0 | 0 | 0 |
| 6 | Jason Bean | Kansas | SR | QB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 6 | Jirehl Brock | Iowa State | JR | RB | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 6 | Jared Casey | Kansas | SO | TE | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 6 | Daniel Hishaw Jr. | Kansas | SO | RB | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 6 | Sam James | WVU | JR | WR | 6 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 6 | Stephon Johnson Jr. | Okla St | FR | WR | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 6 | Quentin Johnston | TCU | JR | WR | 8 | 10 | 6 | 4 | 1 | 1 | 0 | 0 |
| 6 | Malik Knowles | Kansas St | SR | WR | 7 | 4 | 3 | 1 | 1 | 0 | 0 | 0 |
| 6 | Torry Locklin | Kansas | JR | RB | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 6 | Adrian Martinez | Kansas St | SR | QB | 5 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 6 | Kendre Miller | TCU | JR | RB | 7 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 6 | Marvin Mims Jr. | Oklahoma | JR | WR | 6 | 7 | 3 | 2 | 1 | 1 | 0 | 0 |
| 6 | Devin Neal | Kansas | SO | RB | 8 | 6 | 3 | 2 | 1 | 0 | 0 | 0 |
| 6 | Theo Wease Jr. | Oklahoma | JR | WR | 4 | 3 | 3 | 2 | 1 | 0 | 0 | 0 |
| 6 | Brayden Willis | Oklahoma | SR | TE | 6 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |