2022 Big 12 Conference Leaders Interceptions - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | D'Shawn Jamison | Texas | SR | DB | 4 | 1 | 69 | 1 | 0.25 |
| 2 | Colby Reeder | Iowa State | SR | LB | 3 | 2 | 66 | 0 | 0.67 |
| 3 | Josh Newton | TCU | JR | CB | 5 | 2 | 57 | 0 | 0.40 |
| 4 | Daniel Green | Kansas St | SR | LB | 4 | 2 | 50 | 0 | 0.50 |
| 5 | Jahdae Barron | Texas | JR | DB | 4 | 1 | 44 | 1 | 0.25 |
| 6 | Bud Clark | TCU | SO | S | 2 | 1 | 41 | 1 | 0.50 |
| 7 | Dee Winters | TCU | SR | LB | 5 | 1 | 29 | 1 | 0.20 |
| 8 | Jacolby Spells | WVU | FR | DB | 2 | 1 | 27 | 1 | 0.50 |
| 9 | Kenny Logan Jr. | Kansas | SR | S | 4 | 1 | 26 | 0 | 0.25 |
| 10 | Justin Harrington | Oklahoma | SR | DB | 4 | 1 | 22 | 0 | 0.25 |
| 11 | Trey Rucker | Okla St | SR | S | 1 | 1 | 16 | 0 | 1.00 |
| 12 | Eriq Gilyard | Kansas | SR | LB | 3 | 1 | 11 | 0 | 0.33 |
| 12 | Reggie Pearson Jr. | Texas Tech | SR | DB | 3 | 1 | 11 | 0 | 0.33 |
| 12 | Marquis Waters | Texas Tech | SR | DB | 4 | 1 | 11 | 0 | 0.25 |
| 15 | Nick Allen | Kansas St | SR | LB | 4 | 1 | 2 | 0 | 0.25 |