2022 Big 12 Conference Leaders Long All Purpose Plays - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Quentin Johnston | TCU | JR | WR | 5 | 8 | 5 | 4 | 1 | 1 | 0 | 0 |
| 2 | Derius Davis | TCU | SR | WR | 5 | 5 | 2 | 2 | 2 | 0 | 0 | 0 |
| 3 | Monaray Baldwin | Baylor | SO | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Trey Cleveland III | Texas Tech | JR | WR | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Emari Demercado | TCU | SR | RB | 5 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Sam James | WVU | JR | WR | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Malik Knowles | Kansas St | SR | WR | 5 | 4 | 3 | 1 | 1 | 0 | 0 | 0 |
| 3 | Kendre Miller | TCU | JR | RB | 4 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 3 | Marvin Mims Jr. | Oklahoma | JR | WR | 4 | 3 | 2 | 1 | 0 | 0 | 0 | 0 |
| 3 | Jaden Nixon | Okla St | FR | RB | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Jaylin Noel | Iowa State | SO | WR | 3 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Bijan Robinson | Texas | JR | RB | 3 | 4 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | Keilan Robinson | Texas | JR | RB | 4 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Tanaka Scott | Kansas | FR | WR | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Quentin Skinner | Kansas | SO | WR | 3 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Deuce Vaughn | Kansas St | JR | RB | 5 | 3 | 3 | 1 | 1 | 1 | 1 | 0 |
| 3 | Theo Wease Jr. | Oklahoma | JR | WR | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Brayden Willis | Oklahoma | SR | TE | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |