2021 Big 12 Conference Leaders Long All Purpose Plays - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Quentin Johnston | TCU | SO | WR | 3 | 4 | 2 | 2 | 1 | 1 | 0 | 0 |
| 1 | Malik Knowles | Kansas St | JR | WR | 3 | 3 | 3 | 2 | 2 | 2 | 2 | 2 |
| 1 | Abram Smith | Baylor | SR | RB | 5 | 5 | 3 | 2 | 1 | 1 | 0 | 0 |
| 1 | Deuce Vaughn | Kansas St | SO | RB | 3 | 3 | 2 | 2 | 1 | 0 | 0 | 0 |
| 1 | Xavier Worthy | Texas | FR | WR | 5 | 6 | 3 | 2 | 2 | 1 | 0 | 0 |
| 6 | Taye Barber | TCU | SR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 6 | Derius Davis | TCU | SR | WR | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 6 | Erik Ezukanma | Texas Tech | JR | WR | 4 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Keenan Garber | Kansas St | SO | WR | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Jeremiah Hall | Oklahoma | SR | TE | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Jadon Haselwood | Oklahoma | SO | WR | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Xavier Hutchinson | Iowa State | SR | WR | 5 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Sam James | WVU | JR | WR | 3 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Travis Koontz | Texas Tech | SR | TE | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 6 | Kendre Miller | TCU | SO | RB | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Marvin Mims | Oklahoma | SO | WR | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Brennan Presley | Okla St | SO | WR | 4 | 3 | 3 | 1 | 1 | 1 | 1 | 1 |
| 6 | Bijan Robinson | Texas | SO | RB | 5 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Al Walcott | Baylor | JR | CB | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 6 | Marcus Washington | Texas | JR | WR | 5 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 6 | Caleb Williams | Oklahoma | FR | QB | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |