2022 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. Unranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 9 | 57 | 75 | 15 | 147 | 16.3 |
| 2 | Syracuse | 9 | 65 | 84 | 10 | 159 | 17.7 |
| 3 | Clemson | 10 | 51 | 103 | 17 | 171 | 17.1 |
| 4 | Louisville | 10 | 76 | 81 | 16 | 173 | 17.3 |
| 5 | Georgia Tech | 8 | 88 | 68 | 20 | 176 | 22.0 |
| 6 | Boston College | 9 | 70 | 85 | 22 | 177 | 19.7 |
| 7 | North Carolina State | 11 | 50 | 111 | 19 | 180 | 16.4 |
| 8 | Pittsburgh | 11 | 60 | 99 | 29 | 188 | 17.1 |
| 8 | Virginia | 9 | 72 | 96 | 20 | 188 | 20.9 |
| 10 | Virginia Tech | 10 | 75 | 98 | 25 | 198 | 19.8 |
| 11 | Florida State | 11 | 98 | 86 | 21 | 205 | 18.6 |
| 12 | Wake Forest | 11 | 89 | 119 | 13 | 221 | 20.1 |
| 13 | North Carolina | 10 | 88 | 126 | 20 | 234 | 23.4 |
| 14 | Duke | 12 | 91 | 145 | 18 | 254 | 21.2 |