2022 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 1 | 50 | 130 | 48 | 180 | 3.75 | 180.0 |
| 2 | Louisville | 4 | 452 | 376 | 239 | 828 | 3.46 | 207.0 |
| 3 | Duke | 2 | 193 | 312 | 129 | 505 | 3.91 | 252.5 |
| 4 | North Carolina State | 2 | 237 | 306 | 115 | 543 | 4.72 | 271.5 |
| 5 | Syracuse | 2 | 343 | 221 | 121 | 564 | 4.66 | 282.0 |
| 6 | Virginia Tech | 2 | 199 | 382 | 131 | 581 | 4.44 | 290.5 |
| 7 | Florida State | 1 | 132 | 159 | 71 | 291 | 4.10 | 291.0 |
| 8 | Virginia | 1 | 89 | 235 | 69 | 324 | 4.70 | 324.0 |
| 9 | Clemson | 2 | 269 | 396 | 127 | 665 | 5.24 | 332.5 |
| 10 | Georgia Tech | 1 | 284 | 49 | 73 | 333 | 4.56 | 333.0 |
| 11 | Boston College | 2 | 388 | 329 | 121 | 717 | 5.93 | 358.5 |
| 12 | Miami (Florida) | 2 | 123 | 615 | 111 | 738 | 6.65 | 369.0 |
| 13 | Wake Forest | 2 | 400 | 438 | 151 | 838 | 5.55 | 419.0 |
| 14 | North Carolina | 3 | 810 | 836 | 242 | 1646 | 6.80 | 548.7 |