2022 Atlantic Coast Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Louisville | 5 | 610 | 564 | 300 | 1174 | 3.91 | 234.8 |
| 2 | Syracuse | 5 | 512 | 802 | 285 | 1314 | 4.61 | 262.8 |
| 3 | North Carolina State | 5 | 403 | 985 | 325 | 1388 | 4.27 | 277.6 |
| 4 | Virginia Tech | 4 | 455 | 746 | 251 | 1201 | 4.78 | 300.3 |
| 5 | Miami (Florida) | 4 | 340 | 1004 | 219 | 1344 | 6.14 | 336.0 |
| 6 | Wake Forest | 5 | 710 | 973 | 360 | 1683 | 4.68 | 336.6 |
| 7 | Pittsburgh | 5 | 522 | 1217 | 311 | 1739 | 5.59 | 347.8 |
| 8 | Virginia | 3 | 457 | 591 | 208 | 1048 | 5.04 | 349.3 |
| 9 | Florida State | 5 | 879 | 880 | 340 | 1759 | 5.17 | 351.8 |
| 10 | Boston College | 4 | 689 | 728 | 257 | 1417 | 5.51 | 354.3 |
| 11 | Clemson | 5 | 573 | 1266 | 337 | 1839 | 5.46 | 367.8 |
| 12 | Duke | 5 | 690 | 1208 | 348 | 1898 | 5.45 | 379.6 |
| 13 | Georgia Tech | 4 | 983 | 694 | 290 | 1677 | 5.78 | 419.3 |
| 14 | North Carolina | 5 | 1075 | 1320 | 370 | 2395 | 6.47 | 479.0 |