2022 Atlantic Coast Conference Leaders First Downs - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Florida State | 5 | 64 | 58 | 8 | 130 | 26.0 |
| 2 | Pittsburgh | 5 | 60 | 49 | 6 | 115 | 23.0 |
| 3 | Louisville | 5 | 52 | 50 | 11 | 113 | 22.6 |
| 4 | Clemson | 5 | 51 | 54 | 14 | 119 | 23.8 |
| 5 | Duke | 5 | 48 | 52 | 11 | 111 | 22.2 |
| 6 | Syracuse | 5 | 47 | 63 | 10 | 120 | 24.0 |
| 7 | Miami (Florida) | 4 | 46 | 52 | 10 | 108 | 27.0 |
| 7 | North Carolina | 5 | 46 | 61 | 12 | 119 | 23.8 |
| 9 | North Carolina State | 5 | 41 | 57 | 9 | 107 | 21.4 |
| 10 | Wake Forest | 5 | 36 | 63 | 10 | 109 | 21.8 |
| 11 | Virginia Tech | 4 | 30 | 46 | 5 | 81 | 20.3 |
| 12 | Virginia | 3 | 27 | 29 | 11 | 67 | 22.3 |
| 13 | Georgia Tech | 4 | 26 | 35 | 4 | 65 | 16.3 |
| 14 | Boston College | 4 | 23 | 41 | 5 | 69 | 17.3 |