2022 Atlantic Coast Conference Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Louisville | 4 | 15.0 | 112 | 3.75 |
| 2 | Wake Forest | 2 | 8.0 | 55 | 4.00 |
| 3 | Duke | 2 | 7.0 | 52 | 3.50 |
| 4 | Virginia Tech | 2 | 6.0 | 36 | 3.00 |
| 5 | Miami (Florida) | 2 | 5.0 | 28 | 2.50 |
| 6 | North Carolina | 3 | 4.0 | 20 | 1.33 |
| 6 | Florida State | 1 | 4.0 | 19 | 4.00 |
| 8 | Virginia | 1 | 3.0 | 16 | 3.00 |
| 8 | Syracuse | 2 | 3.0 | 15 | 1.50 |
| 10 | North Carolina State | 2 | 2.0 | 18 | 1.00 |
| 10 | Pittsburgh | 1 | 2.0 | 16 | 2.00 |
| 10 | Boston College | 2 | 2.0 | 16 | 1.00 |
| 10 | Georgia Tech | 1 | 2.0 | 8 | 2.00 |
| 10 | Clemson | 2 | 2.0 | 2 | 1.00 |