2022 American Athletic Conference Leaders Rushing Defense - Games in December/January Only through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Memphis | 1 | 35 | 126 | 3.60 | 0 | 35.00 | 126.00 |
| 1 | Houston | 1 | 33 | 129 | 3.91 | 0 | 33.00 | 129.00 |
| 3 | Navy | 1 | 48 | 125 | 2.60 | 1 | 48.00 | 125.00 |
| 4 | SMU | 1 | 42 | 209 | 4.98 | 2 | 42.00 | 209.00 |
| 4 | Cincinnati | 1 | 49 | 287 | 5.86 | 2 | 49.00 | 287.00 |
| 6 | East Carolina | 1 | 38 | 125 | 3.29 | 3 | 38.00 | 125.00 |
| 6 | Tulane | 2 | 80 | 277 | 3.46 | 3 | 40.00 | 138.50 |
| 8 | UCF | 2 | 71 | 431 | 6.07 | 5 | 35.50 | 215.50 |