2022 American Athletic Conference Leaders Passes Defended - Games vs. Conference Teams Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | East Carolina | 8 | 8 | 23 | 31 | 3.88 |
| 1 | Memphis | 8 | 8 | 20 | 28 | 3.50 |
| 3 | Tulane | 9 | 7 | 37 | 44 | 4.89 |
| 3 | Navy | 8 | 7 | 26 | 33 | 4.13 |
| 5 | SMU | 8 | 6 | 20 | 26 | 3.25 |
| 6 | UCF | 9 | 5 | 32 | 37 | 4.11 |
| 6 | Cincinnati | 8 | 5 | 31 | 36 | 4.50 |
| 8 | Tulsa | 8 | 4 | 29 | 33 | 4.13 |
| 8 | Temple | 8 | 4 | 26 | 30 | 3.75 |
| 10 | Houston | 8 | 2 | 32 | 34 | 4.25 |
| 10 | South Florida | 8 | 2 | 16 | 18 | 2.25 |