2022 American Athletic Conference Leaders Passes Defended - Games in October Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Navy | 5 | 5 | 18 | 23 | 4.60 |
| 1 | East Carolina | 5 | 5 | 11 | 16 | 3.20 |
| 3 | Memphis | 4 | 4 | 15 | 19 | 4.75 |
| 3 | Tulane | 3 | 4 | 14 | 18 | 6.00 |
| 5 | Cincinnati | 4 | 3 | 12 | 15 | 3.75 |
| 6 | Tulsa | 4 | 2 | 15 | 17 | 4.25 |
| 6 | South Florida | 4 | 2 | 10 | 12 | 3.00 |
| 6 | Temple | 4 | 2 | 10 | 12 | 3.00 |
| 6 | Houston | 3 | 2 | 9 | 11 | 3.67 |
| 10 | UCF | 4 | 1 | 20 | 21 | 5.25 |
| 10 | SMU | 4 | 1 | 10 | 11 | 2.75 |