2022 American Athletic Conference Leaders Passes Defended - Games in August/September Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Houston | 5 | 5 | 21 | 26 | 5.20 |
| 2 | East Carolina | 4 | 3 | 17 | 20 | 5.00 |
| 2 | UCF | 4 | 1 | 17 | 18 | 4.50 |
| 4 | Cincinnati | 4 | 4 | 14 | 18 | 4.50 |
| 5 | SMU | 4 | 3 | 12 | 15 | 3.75 |
| 5 | Temple | 4 | 2 | 12 | 14 | 3.50 |
| 7 | Memphis | 4 | 5 | 11 | 16 | 4.00 |
| 8 | Tulane | 5 | 4 | 10 | 14 | 2.80 |
| 9 | Tulsa | 4 | 2 | 9 | 11 | 2.75 |
| 9 | Navy | 3 | 1 | 9 | 10 | 3.33 |
| 11 | South Florida | 4 | 4 | 8 | 12 | 3.00 |