2016 Atlantic Coast Conference Leaders Opponent First Downs - Games in August/September Only through 01/09/2017
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Georgia Tech | 4 | 28 | 44 | 3 | 75 | 18.8 |
| 1 | Syracuse | 4 | 38 | 43 | 3 | 84 | 21.0 |
| 3 | Duke | 4 | 26 | 33 | 4 | 63 | 15.8 |
| 4 | Virginia Tech | 4 | 21 | 22 | 6 | 49 | 12.3 |
| 4 | Miami (Florida) | 3 | 16 | 21 | 6 | 43 | 14.3 |
| 4 | North Carolina State | 3 | 16 | 26 | 6 | 48 | 16.0 |
| 7 | Boston College | 4 | 22 | 23 | 7 | 52 | 13.0 |
| 7 | Wake Forest | 4 | 20 | 41 | 7 | 68 | 17.0 |
| 9 | Pittsburgh | 4 | 18 | 55 | 8 | 81 | 20.3 |
| 10 | Florida State | 4 | 40 | 27 | 10 | 77 | 19.3 |
| 10 | Virginia | 4 | 26 | 53 | 10 | 89 | 22.3 |
| 10 | North Carolina | 4 | 44 | 35 | 10 | 89 | 22.3 |
| 13 | Louisville | 4 | 35 | 26 | 11 | 72 | 18.0 |
| 14 | Clemson | 4 | 23 | 23 | 12 | 58 | 14.5 |