2021 Atlantic Coast Conference Leaders Opponent First Downs - Games in August/September Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 4 | 35 | 32 | 4 | 71 | 17.8 |
| 2 | North Carolina State | 4 | 14 | 30 | 5 | 49 | 12.3 |
| 2 | Georgia Tech | 4 | 32 | 28 | 5 | 65 | 16.3 |
| 2 | North Carolina | 4 | 33 | 41 | 5 | 79 | 19.8 |
| 5 | Wake Forest | 4 | 26 | 50 | 7 | 83 | 20.8 |
| 5 | Miami (Florida) | 5 | 43 | 54 | 7 | 104 | 20.8 |
| 7 | Boston College | 4 | 23 | 36 | 8 | 67 | 16.8 |
| 7 | Duke | 4 | 32 | 42 | 8 | 82 | 20.5 |
| 9 | Syracuse | 4 | 34 | 23 | 9 | 66 | 16.5 |
| 10 | Florida State | 4 | 25 | 51 | 10 | 86 | 21.5 |
| 10 | Louisville | 4 | 39 | 41 | 10 | 90 | 22.5 |
| 12 | Pittsburgh | 4 | 17 | 38 | 11 | 66 | 16.5 |
| 12 | Clemson | 4 | 26 | 38 | 11 | 75 | 18.8 |
| 14 | Virginia | 5 | 48 | 44 | 17 | 109 | 21.8 |