2018 Conference USA Leaders Total Defense - Games in November Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Old Dominion | 3 | 502 | 552 | 209 | 1054 | 5.04 | 351.3 |
| 2 | North Texas | 3 | 384 | 864 | 222 | 1248 | 5.62 | 416.0 |
| 3 | Charlotte | 4 | 550 | 949 | 243 | 1499 | 6.17 | 374.8 |
| 4 | Middle Tennessee | 4 | 426 | 699 | 247 | 1125 | 4.55 | 281.3 |
| 5 | Southern Mississippi | 4 | 269 | 782 | 251 | 1051 | 4.19 | 262.8 |
| 6 | UAB | 4 | 474 | 749 | 252 | 1223 | 4.85 | 305.8 |
| 7 | Marshall | 4 | 381 | 570 | 260 | 951 | 3.66 | 237.8 |
| 8 | Louisiana Tech | 4 | 639 | 787 | 267 | 1426 | 5.34 | 356.5 |
| 9 | Florida International | 4 | 976 | 729 | 272 | 1705 | 6.27 | 426.3 |
| 10 | Florida Atlantic | 4 | 748 | 876 | 282 | 1624 | 5.76 | 406.0 |
| 11 | UTSA | 4 | 882 | 1260 | 283 | 2142 | 7.57 | 535.5 |
| 12 | UTEP | 4 | 669 | 1005 | 286 | 1674 | 5.85 | 418.5 |
| 12 | Rice | 4 | 566 | 1208 | 286 | 1774 | 6.20 | 443.5 |
| 14 | Western Kentucky | 4 | 672 | 1150 | 300 | 1822 | 6.07 | 455.5 |