2018 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 1 | 20 | 172 | 47 | 192 | 4.09 | 192.0 |
| 2 | UAB | 1 | 252 | 192 | 54 | 444 | 8.22 | 444.0 |
| 3 | Florida Atlantic | 1 | 316 | 334 | 62 | 650 | 10.48 | 650.0 |
| 4 | Southern Mississippi | 1 | 96 | 245 | 69 | 341 | 4.94 | 341.0 |
| 4 | UTEP | 1 | 345 | 167 | 69 | 512 | 7.42 | 512.0 |
| 6 | North Texas | 1 | 126 | 210 | 77 | 336 | 4.36 | 336.0 |
| 7 | Old Dominion | 1 | 318 | 282 | 83 | 600 | 7.23 | 600.0 |
| 8 | Western Kentucky | 2 | 438 | 345 | 129 | 783 | 6.07 | 391.5 |
| 9 | Rice | 2 | 351 | 615 | 130 | 966 | 7.43 | 483.0 |
| 10 | Marshall | 2 | 267 | 689 | 140 | 956 | 6.83 | 478.0 |
| 11 | Louisiana Tech | 2 | 507 | 434 | 141 | 941 | 6.67 | 470.5 |
| 12 | Florida International | 2 | 461 | 492 | 160 | 953 | 5.96 | 476.5 |
| 13 | Middle Tennessee | 3 | 640 | 514 | 165 | 1154 | 6.99 | 384.7 |
| 14 | UTSA | 3 | 521 | 925 | 195 | 1446 | 7.42 | 482.0 |