2021 Conference USA Leaders Passing - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 3 | 119 | 87 | 73.1 | 1224 | 10.3 | 13 | 2 | 192.20 | 39.7 | 408.0 |
| 2 | Grant Wells | Marshall | FR | QB | 4 | 149 | 96 | 64.4 | 1383 | 9.3 | 5 | 5 | 146.76 | 37.3 | 345.8 |
| 3 | Austin Kendall | La Tech | SR | QB | 3 | 102 | 63 | 61.8 | 837 | 8.2 | 7 | 3 | 147.47 | 34.0 | 279.0 |
| 4 | Max Bortenschlager | FIU | SR | QB | 4 | 116 | 63 | 54.3 | 1105 | 9.5 | 8 | 3 | 151.92 | 29.0 | 276.3 |
| 5 | N'Kosi Perry | FAU | SR | QB | 4 | 136 | 76 | 55.9 | 949 | 7.0 | 7 | 1 | 130.02 | 34.0 | 237.3 |
| 6 | Gavin Hardison | UTEP | SO | QB | 4 | 92 | 55 | 59.8 | 948 | 10.3 | 6 | 5 | 156.98 | 23.0 | 237.0 |
| 7 | Chris Reynolds | Charlotte | SR | QB | 4 | 111 | 67 | 60.4 | 924 | 8.3 | 9 | 2 | 153.44 | 27.8 | 231.0 |
| 8 | Frank Harris | UTSA | SR | QB | 4 | 114 | 75 | 65.8 | 848 | 7.4 | 4 | 2 | 136.35 | 28.5 | 212.0 |
| 9 | Chase Cunningham | MTSU | JR | QB | 4 | 70 | 47 | 67.1 | 638 | 9.1 | 8 | 0 | 181.42 | 17.5 | 159.5 |
| 10 | Bailey Hockman | MTSU | JR | QB | 3 | 66 | 41 | 62.1 | 463 | 7.0 | 4 | 2 | 134.99 | 22.0 | 154.3 |
| 11 | D.J. Mack Jr. | ODU | JR | QB | 4 | 110 | 56 | 50.9 | 556 | 5.1 | 3 | 4 | 95.10 | 27.5 | 139.0 |
| 12 | Jace Ruder | N Texas | SO | QB | 4 | 95 | 51 | 53.7 | 544 | 5.7 | 3 | 5 | 101.67 | 23.8 | 136.0 |
| 13 | Tyler Johnston III | UAB | SR | QB | 3 | 41 | 24 | 58.5 | 390 | 9.5 | 2 | 3 | 139.91 | 13.7 | 130.0 |
| 14 | Dylan Hopkins | UAB | JR | QB | 4 | 39 | 29 | 74.4 | 501 | 12.8 | 7 | 1 | 236.37 | 9.8 | 125.3 |
| 15 | Ty Keyes | USM | FR | QB | 3 | 62 | 31 | 50.0 | 338 | 5.5 | 3 | 3 | 102.09 | 20.7 | 112.7 |
| 16 | Austin Aune | N Texas | SO | QB | 4 | 57 | 24 | 42.1 | 213 | 3.7 | 1 | 0 | 79.29 | 14.3 | 53.3 |
| 17 | Aaron Allen | La Tech | SO | QB | 3 | 19 | 15 | 78.9 | 136 | 7.2 | 0 | 0 | 139.08 | 6.3 | 45.3 |
| 17 | Luke McCaffrey | Rice | FR | QB | 4 | 32 | 16 | 50.0 | 181 | 5.7 | 1 | 3 | 89.07 | 8.0 | 45.3 |
| 19 | Kyle Maxwell | La Tech | FR | WR | 3 | 1 | 1 | 100.0 | 33 | 33.0 | 1 | 0 | 707.20 | 0.3 | 11.0 |
| 20 | Calvin Brownholtz | UTEP | SO | QB | 3 | 6 | 1 | 16.7 | 9 | 1.5 | 0 | 1 | -4.06 | 2.0 | 3.0 |
| 21 | Brenden Brady | UTSA | SR | RB | 4 | 2 | 1 | 50.0 | 8 | 4.0 | 0 | 0 | 83.60 | 0.5 | 2.0 |
| 22 | A.j. Davis IV | UAB | SO | WR | 4 | 1 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0.00 | 0.3 | 0.0 |
| 22 | Xavier Gaines | Marshall | SR | TE | 4 | 1 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0.00 | 0.3 | 0.0 |
Note: To qualify, player must have played in 75% of his team's games.