2021 Conference USA Leaders Passing - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 2 | 106 | 69 | 65.1 | 999 | 9.4 | 10 | 2 | 171.62 | 53.0 | 499.5 |
| 2 | Nicholas Vattiato | MTSU | FR | QB | 1 | 35 | 23 | 65.7 | 270 | 7.7 | 2 | 0 | 149.37 | 35.0 | 270.0 |
| 3 | Gavin Hardison | UTEP | SO | QB | 1 | 27 | 12 | 44.4 | 252 | 9.3 | 1 | 1 | 127.65 | 27.0 | 252.0 |
| 4 | Frank Harris | UTSA | SR | QB | 2 | 64 | 41 | 64.1 | 473 | 7.4 | 4 | 1 | 143.64 | 32.0 | 236.5 |
| 5 | Austin Aune | N Texas | SO | QB | 1 | 32 | 15 | 46.9 | 228 | 7.1 | 0 | 2 | 94.23 | 32.0 | 228.0 |
| 6 | Dylan Hopkins | UAB | JR | QB | 1 | 23 | 19 | 82.6 | 189 | 8.2 | 3 | 1 | 185.97 | 23.0 | 189.0 |
| 7 | Hayden Wolff | ODU | FR | QB | 1 | 28 | 19 | 67.9 | 176 | 6.3 | 0 | 1 | 113.52 | 28.0 | 176.0 |
| 8 | Grant Wells | Marshall | FR | QB | 1 | 26 | 15 | 57.7 | 99 | 3.8 | 0 | 1 | 81.99 | 26.0 | 99.0 |
| 9 | Calvin Brownholtz | UTEP | SO | QB | 1 | 1 | 1 | 100.0 | 51 | 51.0 | 1 | 0 | 858.40 | 1.0 | 51.0 |
| 10 | Brenden Brady | UTSA | SR | RB | 2 | 1 | 1 | 100.0 | 24 | 24.0 | 0 | 0 | 301.60 | 0.5 | 12.0 |
| 11 | Mike DiLiello | MTSU | SO | QB | 1 | 6 | 1 | 16.7 | 6 | 1.0 | 0 | 1 | -8.26 | 6.0 | 6.0 |
| 12 | Joshua Cephus | UTSA | JR | WR | 2 | 2 | 1 | 50.0 | 10 | 5.0 | 0 | 0 | 92.00 | 1.0 | 5.0 |
| 13 | Reynaldo Flores | UTEP | JR | RB | 1 | 1 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0.00 | 1.0 | 0.0 |
Note: To qualify, player must have played in 75% of his team's games.