2021 Conference USA Leaders Passing - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 2 | 108 | 77 | 71.3 | 853 | 7.9 | 6 | 0 | 155.97 | 54.0 | 426.5 |
| 2 | Austin Aune | N Texas | SO | QB | 1 | 26 | 16 | 61.5 | 305 | 11.7 | 4 | 2 | 195.47 | 26.0 | 305.0 |
| 2 | Austin Kendall | La Tech | SR | QB | 2 | 79 | 46 | 58.2 | 610 | 7.7 | 5 | 3 | 136.39 | 39.5 | 305.0 |
| 4 | Frank Harris | UTSA | SR | QB | 1 | 32 | 20 | 62.5 | 280 | 8.8 | 1 | 0 | 146.31 | 32.0 | 280.0 |
| 5 | N'Kosi Perry | FAU | SR | QB | 1 | 33 | 19 | 57.6 | 261 | 7.9 | 1 | 0 | 134.02 | 33.0 | 261.0 |
| 6 | Chris Reynolds | Charlotte | SR | QB | 2 | 53 | 36 | 67.9 | 515 | 9.7 | 5 | 1 | 176.91 | 26.5 | 257.5 |
| 7 | Bailey Hockman | MTSU | JR | QB | 1 | 32 | 19 | 59.4 | 207 | 6.5 | 1 | 1 | 117.78 | 32.0 | 207.0 |
| 8 | Max Bortenschlager | FIU | SR | QB | 1 | 27 | 12 | 44.4 | 185 | 6.9 | 2 | 1 | 119.03 | 27.0 | 185.0 |
| 9 | Ty Keyes | USM | FR | QB | 1 | 24 | 11 | 45.8 | 131 | 5.5 | 2 | 1 | 110.85 | 24.0 | 131.0 |
| 10 | Wiley Green | Rice | SO | QB | 2 | 31 | 17 | 54.8 | 180 | 5.8 | 1 | 3 | 94.91 | 15.5 | 90.0 |
| 11 | Hayden Wolff | ODU | FR | QB | 1 | 17 | 11 | 64.7 | 88 | 5.2 | 1 | 0 | 127.60 | 17.0 | 88.0 |
| 12 | Chase Cunningham | MTSU | JR | QB | 1 | 8 | 7 | 87.5 | 76 | 9.5 | 1 | 0 | 208.55 | 8.0 | 76.0 |
| 13 | Luke McCaffrey | Rice | FR | QB | 2 | 13 | 7 | 53.8 | 95 | 7.3 | 0 | 0 | 115.24 | 6.5 | 47.5 |
| 14 | D.J. Mack Jr. | ODU | JR | QB | 1 | 21 | 7 | 33.3 | 39 | 1.9 | 0 | 2 | 29.88 | 21.0 | 39.0 |
| 14 | Tyler Johnston III | UAB | SR | QB | 1 | 14 | 6 | 42.9 | 39 | 2.8 | 0 | 3 | 23.40 | 14.0 | 39.0 |
| 16 | Dylan Hopkins | UAB | JR | QB | 1 | 3 | 2 | 66.7 | 8 | 2.7 | 0 | 0 | 89.07 | 3.0 | 8.0 |
| 17 | Grayson James | FIU | FR | QB | 1 | 2 | 1 | 50.0 | 6 | 3.0 | 0 | 0 | 75.20 | 2.0 | 6.0 |
| 18 | Aaron Allen | La Tech | SO | QB | 2 | 2 | 1 | 50.0 | -1 | -0.5 | 0 | 0 | 45.80 | 1.0 | -0.5 |
Note: To qualify, player must have played in 75% of his team's games.