2021 Conference USA Leaders Total Defense - Games at Home Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 5 | 642 | 1177 | 346 | 1819 | 5.26 | 363.8 |
| 2 | Middle Tennessee | 5 | 477 | 1020 | 349 | 1497 | 4.29 | 299.4 |
| 3 | UTEP | 6 | 857 | 1276 | 393 | 2133 | 5.43 | 355.5 |
| 4 | Florida Atlantic | 6 | 565 | 1503 | 398 | 2068 | 5.20 | 344.7 |
| 4 | Southern Mississippi | 6 | 1080 | 1084 | 398 | 2164 | 5.44 | 360.7 |
| 4 | Charlotte | 6 | 1378 | 1402 | 398 | 2780 | 6.98 | 463.3 |
| 7 | North Texas | 6 | 895 | 1500 | 401 | 2395 | 5.97 | 399.2 |
| 8 | Old Dominion | 6 | 713 | 1415 | 406 | 2128 | 5.24 | 354.7 |
| 9 | UTSA | 7 | 546 | 1459 | 414 | 2005 | 4.84 | 286.4 |
| 10 | Rice | 6 | 705 | 1847 | 419 | 2552 | 6.09 | 425.3 |
| 11 | Marshall | 6 | 798 | 1365 | 437 | 2163 | 4.95 | 360.5 |
| 12 | Florida International | 6 | 1254 | 1457 | 441 | 2711 | 6.15 | 451.8 |
| 13 | Louisiana Tech | 6 | 1024 | 1733 | 451 | 2757 | 6.11 | 459.5 |
| 14 | Western Kentucky | 6 | 865 | 1571 | 464 | 2436 | 5.25 | 406.0 |