2021 Conference USA Leaders Total Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Rice | 5 | 858 | 1231 | 324 | 2089 | 6.45 | 417.8 |
| 2 | North Texas | 5 | 653 | 949 | 332 | 1602 | 4.83 | 320.4 |
| 3 | Old Dominion | 5 | 595 | 1263 | 335 | 1858 | 5.55 | 371.6 |
| 4 | Louisiana Tech | 5 | 870 | 1045 | 358 | 1915 | 5.35 | 383.0 |
| 5 | Florida Atlantic | 5 | 850 | 1153 | 360 | 2003 | 5.56 | 400.6 |
| 6 | Southern Mississippi | 6 | 819 | 1278 | 395 | 2097 | 5.31 | 349.5 |
| 7 | Florida International | 6 | 1628 | 1410 | 423 | 3038 | 7.18 | 506.3 |
| 8 | UAB | 6 | 615 | 1078 | 429 | 1693 | 3.95 | 282.2 |
| 9 | UTSA | 7 | 868 | 1454 | 456 | 2322 | 5.09 | 331.7 |
| 10 | Charlotte | 7 | 1480 | 1902 | 457 | 3382 | 7.40 | 483.1 |
| 11 | Marshall | 6 | 1302 | 915 | 459 | 2217 | 4.83 | 369.5 |
| 12 | Western Kentucky | 6 | 620 | 1747 | 462 | 2367 | 5.12 | 394.5 |
| 13 | Middle Tennessee | 7 | 800 | 1576 | 474 | 2376 | 5.01 | 339.4 |
| 14 | UTEP | 8 | 889 | 1495 | 546 | 2384 | 4.37 | 298.0 |