2021 Conference USA Leaders Total Defense - Games vs. FCS (I-AA) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTEP | 1 | 118 | 215 | 47 | 333 | 7.09 | 333.0 |
| 2 | UTSA | 1 | 89 | 33 | 49 | 122 | 2.49 | 122.0 |
| 3 | UAB | 1 | 70 | 86 | 50 | 156 | 3.12 | 156.0 |
| 4 | Old Dominion | 1 | 104 | 83 | 56 | 187 | 3.34 | 187.0 |
| 5 | Florida Atlantic | 1 | 29 | 208 | 58 | 237 | 4.09 | 237.0 |
| 6 | Southern Mississippi | 1 | 62 | 90 | 59 | 152 | 2.58 | 152.0 |
| 7 | Marshall | 1 | 71 | 106 | 60 | 177 | 2.95 | 177.0 |
| 8 | Charlotte | 1 | 164 | 50 | 62 | 214 | 3.45 | 214.0 |
| 9 | Florida International | 1 | 96 | 195 | 67 | 291 | 4.34 | 291.0 |
| 10 | Rice | 1 | 94 | 357 | 70 | 451 | 6.44 | 451.0 |
| 11 | North Texas | 1 | 214 | 204 | 75 | 418 | 5.57 | 418.0 |
| 12 | Western Kentucky | 1 | 201 | 195 | 77 | 396 | 5.14 | 396.0 |
| 13 | Middle Tennessee | 1 | 88 | 186 | 80 | 274 | 3.43 | 274.0 |
| 14 | Louisiana Tech | 1 | 103 | 495 | 86 | 598 | 6.95 | 598.0 |